238000004519 manufacturing process Methods 0.000 abstract description 4.OC()=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4 UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances.239000012564 Q sepharose fast flow resin Substances 0.000 claims description 4.229940094657 Botulinum Toxin Type A Drugs 0.000 claims description 4.108010057266 Type A Botulinum Toxins Proteins 0.000 claims description 5.239000012064 sodium phosphate buffer Substances 0.000 claims description 9.239000001509 sodium citrate Substances 0.000 claims description 9.239000011778 trisodium citrate Substances 0.000 claims description 10.239000001963 growth media Substances 0.000 claims description 10.C(=O)CC(O)(CC()=O)C()=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 10 HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound.239000011780 sodium chloride Substances 0.000 claims description 18.FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 28 FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound.238000005571 anion exchange chromatography Methods 0.000 claims abstract description 16.238000005277 cation exchange chromatography Methods 0.000 claims abstract description 17.238000004587 chromatography analysis Methods 0.000 claims abstract description 19.230000002209 hydrophobic Effects 0.000 claims abstract description 20.238000000746 purification Methods 0.000 title claims description 34.229940053031 botulinum toxin Drugs 0.000 title claims abstract description 110.108010043024 Botulinum Toxins Proteins 0.000 title claims abstract description 117. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority claimed from KR1020190043869 external-priority Application filed by (주)제테마 filed Critical (주)제테마 Publication of KR20200121246A publication Critical patent/KR20200121246A/en Application granted granted Critical Publication of KR102447441B1 publication Critical patent/KR102447441B1/en Links ( en Inventor 김재영 남정선 김승호 최승관 임현택 최진희 Original Assignee (주)제테마 Priority date (The priority date is an assumption and is not a legal conclusion. Google Patents KR20200121246A - A Purification Method of Botulinum Toxin KR20200121246A - A Purification Method of Botulinum Toxin
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